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December 4, 2006

Yellow Fever Vaccine: Adverse Events Appear Rare but Real

mosquitoA highly effective live attenuated vaccine, developed more than 60 years ago from the 17D strain of yellow fever (YF) virus, has been a key tool in controlling this disease. The vaccine is given as part of national childhood immunization programs in some endemic areas, and many countries require travelers to provide proof of YF vaccination on entry. Three recent papers report adverse events following YF vaccination.

Researchers in the U.S. report 4 patients (63 and older) with multiple organ-system failure after vaccination with 17D-204 YF. Three died. Researchers found vaccine-related YF virus in the plasma and cerebrospinal fluid of 1 patient and YF antigen in the liver tissue of another. Convalescent sera (available for 2 patients) showed unusually high levels of antibodies.

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ProMetic, Novartis to develop vaccine purification product

novartisDec 4 (Reuters) - ProMetic Life Sciences Inc. (PLI.TO: Quote, Profile , Research) said its UK unit has entered into an agreement with Novartis (NVS.N: Quote, Profile , Research) to develop a synthetic-ligand affinity adsorbent for the purification of protein vaccines.

ProMetic will receive funding from Novartis to screen its chemical combinatorial libraries for ligands suitable for the purification of a new vaccine product developed by Novartis and currently undergoing clinical trials, it added. (Reporting by Sweta Singh in Bangalore)

© Reuters 2006

WHO launches new drive for malaria vaccine by 2015

WHO BANGKOK (Reuters) - The World Health Organization launched a new global effort on Monday to find a vaccine against malaria, which infects up to 500 million people each year, and the donors to pay for it.

The Malaria Vaccine Technology Roadmap aims to develop and license a first generation vaccine by 2015 against the mosquito-borne disease which kills more than one million people a year, mainly African children.

"The Roadmap marks the first concerted global attempt at mapping out a shared plan of action for making a preventive malaria vaccine reality," Marie-Paule Kieny, a top WHO official, said on the sidelines of a vaccine conference in Bangkok.

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December 3, 2006

Fury over mercury vaccine for Scots

fluarixCHILDREN and pregnant women in Scotland are being given a flu vaccination that has poisonous mercury.

Two years ago, the UK Government announced the withdrawal of mercury-based thiomersal vaccinations after they were linked to autism.

But Scottish Health Minister Andy Kerr last week confirmed it is still being used in flu vaccines north of the Border.

In reply to a question from the SSP's Carolyn Leckie, Kerr said: "In this year's flu programme, there is only one vaccine (Fluarix) which contains thiomersal and could be offered to pregnant women and children."

Continue reading "Fury over mercury vaccine for Scots" »

December 2, 2006

Indonesian official: Global bird flu losses tops 2 billion USD

bird fluJAKARTA, Dec. 2 (Xinhua) -- The world's poultry industry suffered approximately 2 billion U.S. dollars in losses due to the bird flu epidemic in the period of September 2005 to September 2006, an Indonesian official was quoted Saturday as saying.

"The global poultry industry has suffered direct losses of 2 billion dollars due to lower prices. This is equal to 14 percent of the total value of world trade," National Avian Influenza Control Commission chairman Bayu Krisnamurthi said, as quoted by major newspaper The Jakarta Post.

Apart from the direct financial losses, Bayu said, indirect losses had also been severe, including lower incomes for poultry breeders, lower poultry consumption and lower nutritional intake as a result of people's unwillingness to consume poultry products.

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December 1, 2006

Bird flu vaccine leaves 10 Canadians dead

tamiflu Two weeks ago, international warnings were posted of adverse reactions to the medication among children and youth. Health Canada didn't issue a public update about the flu drug until Wednesday.
Health Canada's bulletin said that since February 2000, 84 Canadians have had adverse reactions after taking the drug, including 10 who died and seven adults who reported "psychiatric adverse events."

This year alone there was 13 reported reactions to the drug including 3 women aged 95, 88 and 81 that died. Tamiflu is used to treat the flu and combat the H5N1 avian flu virus.

Health Canada spokesman Alastair Sinclair says there is no reason for Canadians to be worried.

source - Digital Journal 

Big mining companies join vaccine maker for HIV trials in South Africa

viraxA small Australian biotech company has secured the help of the world's leading miners to fund clinical trials of its Aids vaccine in South Africa.

In the first programme of its kind, Virax, which is listed on the Australian stock exchange and plans to float on Aim next year, has set up a non-profit organisation for corporate donors with operations and interests in South Africa and other neighbouring countries, and whose workforces are affected by the disease.

Eight companies including Rio Tinto and BHP Billiton will fund the trials, expected to cost between $5m and $6m.

There are more than six million people with HIV/Aids in the country. The incidence of the disease varies - in KwaZulu-Natal, for example, up to 35% of the population is HIV positive, and 41% of those in the penal system have the virus.

Continue reading "Big mining companies join vaccine maker for HIV trials in South Africa" »

Perth professor in HIV vaccine bid

Simon MalalA Perth researcher playing a key role in the fight against HIV-AIDS says there could be a breakthrough in vaccines within 10 years.

Professor Simon Mallal leads a team of 42 scientists at a collaborative research centre in Perth who have already notched up a breakthrough in HIV-AIDS research.

In 2002, the team discovered that a person's genetics will determine how they will react to HIV and how they should be treated.

Continue reading "Perth professor in HIV vaccine bid" »

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